Posted by ed_uk on November 20, 2004, at 14:57:31
In reply to Re: Treatment in England - lofepramine » ed_uk, posted by KaraS on November 19, 2004, at 15:31:13
To Kara,
I find lofepramine (Gamanil) very easy to tolerate, easier than SSRIs in fact. Lofepramine is a norepinephrine reuptake inhibitor like desipramine. It is partially metabolised to desipramine. It is much less dangerous in overdose than other TCAs. It is also much less cardiotoxic. Liver damage is a very rare side effect (but other TCAs cause liver damage occasionally too, it's not clear that there's anything special about lofepramine here). Personally, I don't find it stimulating or sedating- it's fairly neutral for me. Some people find it stimulating. The anticholinergic side effects are very weak. I don't have any! It doesn't generally cause any weight gain. It's antihistamine effect is negligible. It causes insomnia for some people. Out of the TCAs I've tried amitriptyline and dothiepin. They were both intolerable. Never tried reboxetine or milnacipran though. Reboxetine is on the market in England as Edronax. Milnacipran is not available here.
Regards,
Ed.
poster:ed_uk
thread:416530
URL: http://www.dr-bob.org/babble/20041118/msgs/418317.html