Posted by jrbecker on November 17, 2004, at 12:20:03
In reply to Re: Nicotine Receptors Target for Anti-depressants, posted by linkadge on November 17, 2004, at 11:33:51
> Admittedly, I did not read the entire post, but
> what I don't understant is that, both nicotinic agonists and nicotinic antagonists seem to act as antidepressants.
>
>
> LinkadgeFrom the DISCUSSION section...
"The idea that both nicotine and nicotinic receptor antagonists can produce antidepressant-like effects seems paradoxical; however, chronic nicotine administration can result in desensitization and inactivation of nAChRs, resulting in a functional antagonism (Gentry and Lukas 2002). Thus, the antidepressant-like effects of chronic nicotine might be related to its action as a functional antagonist of nAChRs rather than its agonist properties at those receptors."
poster:jrbecker
thread:417063
URL: http://www.dr-bob.org/babble/20041113/msgs/417093.html