Posted by zeugma on November 1, 2004, at 18:31:37
In reply to Re: no more Cymbalta for now » zeugma, posted by karaS on November 1, 2004, at 0:30:14
> > > Most likely I'll just sit here thinking about this and changing my mind a million times before I do anything.
> > >
> > > How are those purple dancing elephants?
> > >
> > > K
> >
> > The purple dancing elephants are OK. But they make a lot of noise :)(plus it smells like a circus in here).
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> You must have an incredible imagination!
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> Spending so much time in REM has its benefits, along with the obvious drawbacks.> > Parnate sounds like an excellent idea. You might have to deal with the fatigue, and the dietary restrictions, but most sources say Parnate has fewer s/e than Nardil.
>
> 2 more thoughts before I talk to my doctor again:
> reboxetine and Amisulpride. The word on reboxetine as an AD isn't that great, is it? Hopefully, I'm wrong about that. Amisulpride and Sulpiride - are they related? I believe I read that one or both of them are the only medications specifically for my DA receptor problem. I would take it in AD dosage. I know that they are APs but what makes a medication an AP? If they're taken at AD dosage, do they still carry a risk of TD/movement disorder?
>
I wish I could recommend Strattera. The drug unquestionably has an AD effect. But the sedation/fatigue effect that I eventually got from it seems far from uncommon. Reboxetine has a bad reputation here, and most say desipramine is a superior AD. But in theory reboxetine should be a good AD.AP's are drugs that block the negative and positive symptoms of psychosis- delusions, paranoia, as well as apathy and withdrawal. The negative symptoms of schizophrenia and depression are similar, which is why many AP's have AD effects, at least at lower doses. AP's block the D2 receptor, which is thought to underlie the efficacy against the positive symptoms- delusions and such- while they also block 5HT-2 receptors which is thought to improve the positive symptoms. I think amisulpiride is a cleaner version of sulpiride.
Something you might want to consider is Abilify. It is a partial agonist of D2 receptors. In theory, if your D2 receptors are overly sensitive, then Abilify will desensitize them, much like buspirone is thought to desensitize the 5HT-1A receptor. I have also read claims that Abilify is the only AP besides clozapine that does not carry the risk of tardive dyskinesia. I would say Seroquel would be the least likely of the others to induce TD.
-z>
> > Right now I'm in a fallow period. I'm positive, given my response to provigil and the recent discoveries of orexigenic transmission, that many of my problems localize in the hypothalamus. I plan to spend the coming months researching this in my spare time.
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> Other than uderstanding more about the origins of your issues, what can your research tell you? Can it lead to specific treatment?
>
> > I took a 'holiday' from Ritalin today (only 20 mg). I feel completely exhausted.
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> It sounds like you could use the rest...
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> K
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poster:zeugma
thread:406397
URL: http://www.dr-bob.org/babble/20041029/msgs/410304.html