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Re: Cymbalta and coffee? » karaS

Posted by zeugma on October 28, 2004, at 18:32:11

In reply to Re: Cymbalta and coffee? » zeugma, posted by karaS on October 28, 2004, at 0:20:14

> >
>
> Hey z,
>
> Missed you these past few days!

Same here. I've been wretchedly busy.
>
> Re: Cymbalta, many people ARE finding it to be much cleaner than Effexor. I didn't have a good experience on Effexor until I took the XR version. Maybe it's not fair to compare the two until there's an XR version of Cymbalta.
>
I read on the PI sheet that Cymbalta is enteric coated to provide timed release. Or at least I think I read that. In any case, it's the cymbalta currently available that needs to be evaluated for cleanliness, especially since we don't always have infinite time at our disposal in our evaluations of meds.

> I'm wondering if I shouldn't have tried a higher dose of Effexor. I tolerated it so well (as long as it was XR). Maybe I should have gone up to 300.
>
I'm guessing you don't have a dr. you trust to discuss your concerns about increased blood pressure on the higher doses of Effexor. That's a shame, because it's a necessity. Your concerns about blood pressure are a real concern that any M.D. should be able to provide reliable advice about.

> I'm curious why you suggested maprotiline. I used to take a small amount of it for years for sleep. I tolerated it well but I gained too much weight from it.

I suggested maprotiline because it is the most NE-selective (relative to serotonin) reuptake inhibitor on the market that I'm aware of. It is also has less anticholinergic effects than desipramine, the least anticholinergic of the TCA's, according to the chart I am going by:

http://www.primarypsychiatry.com/pdf/art_453.pdf

(If you scroll down past the dull text you get to the useful info.) I seem to remember that you had tachycardia from desipramine and nortriptyline. That sounds like an anticholinergic s/e.

As for weight gain, that's because of MAP's potent H1 blockade, but if you are using it at doses higher than those needed for sleep, its NE reuptake inhibition might counteract the sleepiness and weight gain. At the very least, you might be less depressed. It's easier to lose weight in that condition. And a good night's sleep is not a useless commodity. >

> Caffeine isn't an AD for me but it's sure the best drug I've ever taken for energy!
>
The Ritalin LA at 50 mg requires supplementation from caffeine. I can tell you that it seems much less stimulating than Provigil, and provides none of the 'jolting' effects of Strattera. It is doing something, though. Ask me in a week about it.

> Hope you're doing well.
>

I think I am, considering the circumstances. I know you're doing the same.

-z


> Kara
>

-z


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poster:zeugma thread:406397
URL: http://www.dr-bob.org/babble/20041024/msgs/408527.html