Posted by zeugma on July 6, 2004, at 22:44:11
In reply to Re: vegetative depression, nortriptyline dosage » zeugma, posted by SLS on July 6, 2004, at 21:47:49
> > > Hi Zeugma.
> > >
> > > I'm afraid that I am having trouble making the connections between these abstracts. How do you interpret them?
> > >
> > >
> > > - Scott
> >
> > Hi Scott
> >
> > brainwave states range from beta to delta:http://brain.web-us.com/brainwavesfunction.htm
>
>
> That's a nice little review. I guess I was wondering if there was any data linking tolerance to the REM suppressing effects of ADs to loss of efficacy. Drugs worked best for me when they suppressed REM. 120mg of Parnate doesn't do it anymore, if you can believe it.
>
>
> - Scott
>
>
J.A. Hobson, in "The Dream Drugstore", discusses how SSRI's can suppress actual REM stage sleep but increase dreaming. He says that since serotonin controls eye movements, the saccadic eye movements typical of REM become prevalent in other stages of sleep, resulting in increased dreaming despite diminished time spent in actual REM stage. This increased dreaming, according to him, does indeed cause 'poopout', since it deprives the brain of restorative sleep (since the eye movements, and presumably the accompanying brain activity are no longer confined to REM). What he says implies that noradrenergic AD's would be less likely to have this effect of increasing dream states, since it is 5-HT that is responsible for the saccadic eye movements. This can't be a global account of poopout, because any class of AD can poopout, unfortunately :(
poster:zeugma
thread:363009
URL: http://www.dr-bob.org/babble/20040704/msgs/363617.html