Posted by zeugma on July 6, 2004, at 15:43:57
In reply to Re: vegetative depression, nortriptyline dosage » zeugma, posted by SLS on July 6, 2004, at 15:06:30
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> > > > I'm not worried about anticholinergic effects (I think I'm hyper-cholinergic),
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> > > Do you dream too much?
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> > YES!! i go into REM immediately after falling asleep, and usually wake up (when not on TCA) with a sensation of having dreamed myself into exhaustion. does this happen to you?
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> Not really, but it is consistent with your hypothesis that your system is in a hypercholinergic state. How did you come to this conclusion?
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> I would say that I hit REM sometime between 1/2 to 1 hour after falling asleep. This is consistent with endogenous depression. In healthy individuals, REM latency is closer to 90 minutes.
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> - Scott
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II began getting hypnagogic/hypnopompic hallucinations (dreamlike states mixed with features of waking consciousness) at the age of 23. At times I have the 'dream within a dream' (false awakening) experience and when I actually wake up, less than 5 minutes have gone by on the clock. As far as I know, the images formed during stage 1 sleep do not have this quality at all; it aapears to be confined to REM states.These hallucinations/premature REM events are blocked to varying extents by nortriptyline, buspirone, and Strattera, but not by clonazepam, and of these four medications, only clonazepam is not a strong REM inhibitor.
When I took Strattera at the same time as clonazepam, and then fell asleep, I did not experience these states, consistent with Strattera's rapid absorption and powerful REM-suppressing effect (for more on this see http://www.sro.org/pdf/863.pdf, which used Strattera's cousin, nisoxetine). When I fell asleep after taking Provigil, I experienced extremely vivid dreams and did not feel rested at all.
poster:zeugma
thread:363009
URL: http://www.dr-bob.org/babble/20040704/msgs/363523.html