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Re: nortriptyline, citalopram toxicity » Vera

Posted by zeugma on April 11, 2004, at 12:43:44

In reply to Re: nortriptyline, citalopram toxicity, posted by Vera on April 11, 2004, at 10:59:05

Desipramine and nortriptyline are close chemical cousins. So if the ability to process desipramine is blocked, then it's likely that nortriptyline will be subject to the same problem. Since Lexapro is probably a much weaker inhibitor of the relevant enzymes than Prozac or Paxil, the interaction is likely to be less dangerous, but it's still something to be aware of. Getting a plasma test for nortriptyline is standard practice, anyway- it is the antidepressant with the most well-defined 'therapeutic window', meaning plasma levels have to be within a certain range for optimal results to occur. I got a plasma test for nortriptyline last year, and had my dosage adjusted as a result. This made the drug more effective even though there was no concern about toxicity- it turned out my plasma levels had been too low.

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