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Re: nortriptyline, citalopram toxicity

Posted by zeugma on April 10, 2004, at 23:21:56

In reply to Re: nortriptyline, citalopram toxicity » Vera, posted by chemist on April 10, 2004, at 21:27:22

Apparently lexapro can raise the plasma levels of nortriptyline. (Now I see why my dr. wasn't adamant that I try an SSRI before a benzo to control my anxiety.) Nortriptyline is only effective within a fairly limited range- long before it becomes toxic, it will become ineffective. You can ask your dr. about a plasma level test on the nortriptyline.

I think it is reasonable to raise the Lexapro to 20 mg if you are still depressed and have given 10 mg a reasonable trial. It takes about a month at a given dose of an antidepressant (whether pamelor or Lexapro) to see if it is adequate. You should not hesitate to share your concerns with your doctor.


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