Posted by Karen Moore on February 4, 2004, at 21:49:55
In reply to Re: doxepin, remeron, whatever.. thread is off-top » Karen Moore, posted by scott-d-o on February 2, 2004, at 22:47:30
> hey karen,
>
> I did give the gel caps a try, just for fun thou.. I took the whole bottle, which was 300mg; not all that high for a recreational dose. it reminds me most of ketamine ("special k", also a nmda antagonist), due to the same type of mind/body disassociation effect; it's somewhat amusing every once in a while but nothing I'd want to do on a regular basis. Also, it enhances music somewhat, which was the only thing I liked about weed (but could never tolerate it cause of extreme paranoia and panic).. I've only used DXM on one other occasion (syrup) and I much preferred the experience with the gel caps..
>
> It could just be my imagination, but I think my dexedrine did produce a little euphoria the next day (it never usually does.) NMDA antagonists administered by themselves indirectly cause dopamine release so there's no doubt DXM and amphetamine would complement each other well. They come in 15mg gelcaps, I think one per day could do a lot for amphetamine tolerance and if you do a search on this board I think you will find some people have had success using DXM and for this purpose..
>
> however, I don't know exactly how bipolars react to nmda antagonists so perhaps you should look into that before doing any experimenting.. my intuition tells me that, if anything, it would help stabilize you, since most bipolar meds act strikingly similar to DXM in the brain. I wonder why this person thinks memantine could destabilize a bp?
>
> scott
Hey scott,
Hmm...interesting, but I definitely could do without the dissociative effect, I get that from my own naturally wacked chemistry. Though for a short time it might be entertaining, I don't usually have anxiety about such things. Something to keep in mind w. adderall/dex, if I could get by with a smaller dose I'm guessing that would mean less side-effects. Interesting...
As for memantine, dubovsky specializes in treatment resistance and bipolar. He indicated that his clinical experience was that it could destabilize (very sensative patients) but specified that the research did not yet show this. So, either it's just random or it's one of those pesky gaps between research, theory, and reality! Who knows, it could be some secondary effect unrelated to NMDA. Memantine appears to have significant antagonistic effects at the 5HT3 receptor, but I can't focus long enough to remember or figure out how that might effect a bipolar...
later,
KM
poster:Karen Moore
thread:306217
URL: http://www.dr-bob.org/babble/20040204/msgs/309561.html