Posted by Sad Panda on February 4, 2004, at 21:47:11
In reply to Re: Doxepin v Mirtazapine, posted by scott-d-o on February 4, 2004, at 19:30:39
>
> umm, huh? yes that's true, doxepin is much more like effexor than mirtazapine.. both block reuptake of serotonin and norepinephrine, I simply said doxepin has a bit higher affinity for the NE transporter, while effexor has a higher affinity for the serotonin transporter.. all the tricyclics do this.. mirtazapine does not block the reuptake of either, therefore it is not similar to either effexor or doxepin. ugh, I'm done w/this thread..
>Scott, not all tricyclics block the reuptake of serototin, Doxepin is extremely weak & clinically insignificant at serotonin reuptake blocking. Trimipramine, another tricyclic, does not block the reuptake of serotonin or norepinephrine. To say Doxepin & Efexor are similar would be nonsense, Efexor is a stimulating med closest to SSRI's while Doxepin is a heavily sedating tertiary tricyclic. Do you remember discussing H1 blockade? Doxepin is the 2nd most powerfull H1 blocker on the market, Mirtazapine is the only thing that is stronger, this is why I say they are similar, their strongest action is on H1 blockade which makes them heavily sedating, other characteristics of these 2 meds take a back seat to this.
Karen, I haven't used Doxepin for sleep, it would be my 2nd choice after Mirtazapine. I have tried up to 80mg of Temazepam consumed with a stiff scotch & still stayed awake to watch the sunrise yet again. 30mg of Mirtazapine, OTOH, just turns off my mind & stops all the stupid thoughts from going around & around. It doesn't knock me out, but after I have swallowed it I can go to sleep whenever I want.
Sorry for my obsessive ramblings.
Cheers,
Panda.
poster:Sad Panda
thread:306217
URL: http://www.dr-bob.org/babble/20040204/msgs/309555.html