Posted by Betternow on January 29, 2004, at 19:40:05
In reply to Re: ...Designer.... It will......... » Betternow, posted by Questionmark on January 29, 2004, at 15:08:15
>
> i understand how that alpha1 adrenergic antagonism would be a pain i think. But alpha2 antagonism shouldn't be a bad thing, unless it is too severe or you are extremely susceptible to panic or anxiety. And i'm not sure about Serzone or Geodon, but i know that trazadone's and mirtazapine's adrenergic effects are antagonism of alpha2 receptors. This increases release of NE and, to some extent, 5-HT, and it is good for sexual functioning, esp. that of males. i believe this is actually why one of trazadone's potential dangerous side effects is priapism (b/cz of its alpha-2 antagonism).
>Hi ?
I really appreciate your response!
I'm not even close to being smart about this stuff, but based on clinical pharmacology from product information, you are correct about Mirtazapine's therapeutic benefits from antagonism of alpha2 autoreceptor. This is a good thing! I guess.
But it also says it antagonizes alpha1 and this may be responsible for orthostatic hypotension-not so good!
If anybody out there is really up on this stuff, I would appreciate something like "Receptors for Dummies"
I don't know the difference between a "receptor", an "autoreceptor" or certainly a "heteroreceptor".
poster:Betternow
thread:306751
URL: http://www.dr-bob.org/babble/20040127/msgs/307057.html