Posted by Questionmark on January 29, 2004, at 15:08:15
In reply to I NEED A DESIGNER DRUG ASAP!!!!!! It will........., posted by Betternow on January 29, 2004, at 0:10:43
> antagonize 5ht2a, agonize 5ht1a, it could have some reuptake inhibition-5ht and/or NE. IT MUST NOT effect alpha1 adrenergic receptors, the cholinergic muscarinic receptors, or the histamine H1 receptors.Geodon is close but its alpha1 antagonism kills it for me. I cannot do alpha blockers, they make me a stupid zobie with a bad case of sinusitus.
>
> In the abscence of such aperfect drug, Anyone have any ideas on counteracting the Alpha1 adrenergic antaganism present in drugs like serzone, geodon, trazadone, mirtazapine, etc. It is that property of these drugs that make us feel like crap.i understand how that alpha1 adrenergic antagonism would be a pain i think. But alpha2 antagonism shouldn't be a bad thing, unless it is too severe or you are extremely susceptible to panic or anxiety. And i'm not sure about Serzone or Geodon, but i know that trazadone's and mirtazapine's adrenergic effects are antagonism of alpha2 receptors. This increases release of NE and, to some extent, 5-HT, and it is good for sexual functioning, esp. that of males. i believe this is actually why one of trazadone's potential dangerous side effects is priapism (b/cz of its alpha-2 antagonism).
> Has anyone got an idea on how to counteract. Could one take an Alpha1 adrenergic AGONIST to offset?
>
> Sick and tired of the SSRIs-gotta find alternative
>
> Not so Betternow
poster:Questionmark
thread:306751
URL: http://www.dr-bob.org/babble/20040127/msgs/306925.html