Posted by BrittPark on September 16, 2003, at 22:12:13
In reply to Re: OpioidsDepression:TheKey2LockTolerance:NALTRE » Kon-shuss, posted by craig allen on September 16, 2003, at 21:29:44
> hey kon-shuss. have you been on the naltrexone with opioids treatment plan, or have you only read about it? sounds almost too good to be true. opioids with little or no tolerance? i guess they put a man on the moon though and someone even made a seedless watermelon. i'd be more encouraged if i heard from some people who actually have taken this combo and had it work. anyone out there?
Oxytrex, at least, has made it through phase II trials, which have demonstrated safety and efficacy in small studies of 10s of people. The studies, according to Medline have not been published. Oxytrex is now heading into phase III trials which will include 100s of subjects, and should demonstrate clearly whether the formulation produces less or, one hopes, no tolerance. The question, "is OxyTrex effective at improving mood?", the one most relevant to psychiatry will undoubtedly not be answered, at least directly. Pain therapeutics is concerned with OxyTrex's efficacy as an analgesic not as a mood enhancer. I read some months ago that the developers of OxyTrex claimed that it was not euphoriant. This would be bad news for psychiatric purposes, but I have some hope that Pain Therapeutics is trying to avoid any approval hang-ups from "abusibility" concerns by claiming non euphoriant status.
I think, from my perusal of the animal studies, that OxyTrex will turn out to be, if not completely non-tolerance-building, much less so than simple oxycodone. It will probably be a few years before there will be even any anecdotal evidence of its efficacy or non-efficacy for mood disorders.
Remember good clinical studies are a much better guides than individual experiences, to the effectiveness of drugs.
Cheers,
Britt
poster:BrittPark
thread:120871
URL: http://www.dr-bob.org/babble/20030912/msgs/260845.html