Posted by DSCH on August 21, 2003, at 11:47:42
In reply to Re: Remeron, posted by Caleb462 on August 21, 2003, at 10:04:47
>
> > Also look at my back and forth with Francesco. On SLS's chart Remeron is a 5HT and NE *antagonist*. 5HT antagonism would seem to be contraindicated!
> >
>
> No, no, no! Selective 5-HT antagonism is not contraindicated with OCD. You have to realize that the end result of SRI therapy in OCD is reduced activity at certain sertonin receptors, thus antagonism of 5-HT2/5-HT3 simply mimics the final response one would achieve with an SRI.
>
> Also, the "gold standard" OCD medication, Anafranil, is itself a 5-HT2a ANTAGONIST.
>
> One more thing, the adrenergic system is tricky, and remeron's antagonistic effect at alpha-2 adrenergic receptors actually increases NE release.
>
> McPac is correct, there have been studies showing Remeron as an effective drug for OCD.I thank you for the information. However, it would be nice to have it delivered with less adrenal content. ;-)
poster:DSCH
thread:251624
URL: http://www.dr-bob.org/babble/20030818/msgs/252759.html