Posted by Caleb462 on August 21, 2003, at 10:04:47
In reply to Remeron » McPac, posted by DSCH on August 19, 2003, at 7:34:58
> Also look at my back and forth with Francesco. On SLS's chart Remeron is a 5HT and NE *antagonist*. 5HT antagonism would seem to be contraindicated!
>No, no, no! Selective 5-HT antagonism is not contraindicated with OCD. You have to realize that the end result of SRI therapy in OCD is reduced activity at certain sertonin receptors, thus antagonism of 5-HT2/5-HT3 simply mimics the final response one would achieve with an SRI.
Also, the "gold standard" OCD medication, Anafranil, is itself a 5-HT2a ANTAGONIST.
One more thing, the adrenergic system is tricky, and remeron's antagonistic effect at alpha-2 adrenergic receptors actually increases NE release.
McPac is correct, there have been studies showing Remeron as an effective drug for OCD.
poster:Caleb462
thread:251624
URL: http://www.dr-bob.org/babble/20030818/msgs/252725.html