Posted by Larry Hoover on June 22, 2003, at 8:35:54
In reply to Lar, Re: nutrients and asthma, posted by McPac on June 21, 2003, at 23:50:21
> Also, niacinamide may have good effect, as it reduces histamine release from mast cells. 500 mg, as needed.
>
> >>>>>>Lar, doesn't niacin help BUILD histamine?Most of the relevant research was done thirty years ago, and on other continents. I was able to track down some literal quotes from certain articles (a few weeks ago, not reproduced here), but most articles do not have abstracts available for perusal. I've pasted a few references in, because even the titles are pretty clear.
Int Arch Allergy Appl Immunol. 1976;50(6):729-36.
Inhibition by nicotinamide of antigen-induced histamine release from mouse peritoneal mast cells.
Wyczolkowska J, Maslinski C.
The in vitro antigen-induced histamine release from mouse peritoneal mast cells actively sensitized with IgE antibodies was inhibited by nicotinamide. The drug was either given in vivo to the sensitized mice (once daily 100 mg/kg) for 7 days before an in vitro experiment or incubated in vitro (in concentrations 1-40 mM) with sensitized mast cells before an antigen challenge. The possible action of nicotinamide on the mechanisms involved in the regulation of antigen-induced histamine release from mast cells is discussed.
Bekier E, Czerwinska U.
The effect of nicotinamide on the experimental asthma in guinea pigs.
Acta Physiol Pol. 1973 Nov-Dec;24(6):887-9. No abstract available.
Bekier E, Wyczolkowska J, Szyc H, Maslinski C.
The inhibitory effect of nicotinamide on asthma-like symptoms and eosinophilia in guinea pigs, anaphylactic mast cell degranulation in mice, and histamine release from rat isolated peritoneal mast cells by compound 48-80.
Int Arch Allergy Appl Immunol. 1974;47(5):737-48.
Bekier E, Szyc H, Czerwinska U, Maslinski C.
The influence of nicotinamide on the course of experimental bronchial asthma in guinea pig.
Agents Actions. 1973 Oct;3(3):176. No abstract available.Bekier E, Maslinski C.
Antihistaminic action of nicotinamide.
Agents Actions. 1974 Aug;4(3):196. No abstract available.Wyczolkowska J, Maslinski C.
Inhibition by nicotinamide of a homologous PCA reaction and antigen-induced histamine release from isolated rat peritoneal mast cells.
Agents Actions. 1974 Aug;4(3):202-3.
> This year is different from my last thirty years.
>
> >>>>>>>>> What supplements seem to be helping so much (niacin? selenium? any others?) I ask because my brother has asthma. Thanks!I mentioned B-3 derivatives and selenium, but I should also have made note of vitamin C and magnesium. I'm a tad more focussed on the water-solubles this year. B-12 is in better supply this year, too.
Lar
poster:Larry Hoover
thread:235091
URL: http://www.dr-bob.org/babble/20030619/msgs/235994.html