emotional effects of NE reuptake inhibitors » turalizz

Posted by zeugma on June 19, 2003, at 21:45:33

In reply to Re: Reboxetine (not approved in U.S.? FDA blows!) » NikkiT2, posted by turalizz on June 19, 2003, at 19:27:15

> > I tried reboxatine a good couple of years ago (so its been lisenced in UK alot longer than this past summer) and only lasted 3 weeks.. and for the three weeks I was on it, I cried and cried and cried the whole time.. and I am not someone who cries easily..
> >
> > Nikki
>
> See, that's what reboxetine does. It somehow seems to "intensify" the emotions. I became very emotional myself when I was on reboxetine.
> But remember that apathy is a synptom of depression, and SSRI's are no good for that.
>
> Don't forget that depression is not like flue, symptoms change from person to person.
> So why leave out something that can be useful to many patients?
>
I wish there was more written on the differential aspects of these drugs instead of searching wildly for the "magic bullet" that will cure depression. Reboxetine and the noradrenergic TCA's have a different 'feel' to them which fits some personality types and disorders better than the SSRI's. The emotional intensification these drugs can induce is probably what makes them less suitable for OCD types, as OCD'ers already have enough emotional investment in their surroundings and don't need that level boosted even further. Similarly people undergoing a profound transient depression could probably use some of the apathy SSRI's can deliver.
This reasoning was behind the introduction of the concept of 'endogeneous depression' to explain what the TCA's reversed. Someone who is endogeneously depressed is not reacting to external circumstances in a functional way: the TCA's intensify emotional response in these people to bring them back to the normal variation in mood that people generally feel. It's clear that not all, or even most, depression can be 'endogeneous' or the SSRI's could never have displaced the TCA's in popularity. But the supposition that there is a type of depressed individual who responds best to NE reuptake inhibitors remains a tenable one.

Thread

Reboxetine (not approved in U.S.? FDA blows!) McPac 6/19/03
...
Re: SSRI conspiracies--nonexistent. McPac 6/19/03
Caleb, (not approved in U.S.? FDA blows!) McPac 6/19/03
Re: SSRI conspiracies--nonexistent. McPac 6/19/03
Re: Caleb, (not approved in U.S.? FDA blows!) Caleb462 6/19/03
Re: Lilly controls the FDA--NOT » stjames Jack Smith 6/19/03
Re: SSRI conspiracies--nonexistent. Jack Smith 6/19/03
Re: efficacy and approval Snoozy 6/19/03
Re: Reboxetine (not approved in U.S.? FDA blows!) » McPac turalizz 6/19/03
Re: Reboxetine (not approved in U.S.? FDA blows!) NikkiT2 6/19/03
Re: SSRI conspiracies--nonexistent. Caleb462 6/19/03
Re: Reboxetine (not approved in U.S.? FDA blows!) » NikkiT2 turalizz 6/19/03
tura Reboxetine (not approved in U.S.? FDA blows!) McPac 6/19/03
emotional effects of NE reuptake inhibitors » turalizz zeugma 6/19/03
Follow the money » McPac Barbara Cat 6/19/03
McPac.... Caleb462 6/19/03
BarbCat, Re: Follow the money McPac 6/19/03
Question for McPac re OCD » McPac Barbara Cat 6/20/03
Caleb, Re: McPac.... McPac 6/20/03
Re: emotional effects of NE reuptake inhibitors » zeugma Barbara Cat 6/20/03
Re: Reboxetine (not approved in U.S.? FDA blows!) HenryO 6/20/03
I didn't like Reboxetine one bit HenryO 6/20/03
BARBCAT, Re: Question for McPac re OCD McPac 6/20/03
Redirect and please be civil » Jack Smith Dr. Bob 6/22/03
Re: BARBCAT, Re: Question for McPac re OCD » McPac Barbara Cat 7/2/03

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URL: http://www.dr-bob.org/babble/20030619/msgs/235272.html