Posted by Questionmark on May 23, 2003, at 23:16:04
In reply to Re: Parnate pharmacology., posted by djmmm on May 23, 2003, at 9:43:01
>"There is still a multitude of information to learn about MAO inhibitors, they are complex drugs because MAO is a complex enzyme, and there are most definitely other amines (trace or otherwise) effected. There is evidence that tranylcypromine binds to reuptake pumps (5-ht, DA and NE). I came across an old study on pubmed which stated that tranylcypromine and phenelzine released norepinephrine from stores, while the MAOIs pargyline and iproniazid did not, and studies of tranylcypromine that stated dopamine release was part of it's pharamacology."
Wow, that's the kind of information i was looking for, thank you. It seems true too. That's kind of disappointing though. i wonder what just a pure irreversable MAO inhibitor would be like. i also wonder if phenelzine has any serotonin reuptake inhibiting properties as well.
poster:Questionmark
thread:227776
URL: http://www.dr-bob.org/babble/20030520/msgs/228746.html