Re: Parnate pharmacology.

Posted by Paulie on May 20, 2003, at 12:18:58

In reply to Parnate pharmacology., posted by Questionmark on May 19, 2003, at 21:52:06

I noticed more stimulation on 20mg/d parnate than on 45mg/d nardil. What's interesting is that on nardil my MAO inhibition must have been anywhere in the range of approx. 40-95%. On parnate MAO inhibition was probably no greater than 25%. This data is from http://www.vh.org/adult/provider/psychiatry/CPS/17.html
There is also a chart correlating parnate dosing with MAO inhibition-http://www.vh.org/adult/provider/psychiatry/CPS/17Figure2.html
This is total MAO activity. Wish they had separated into MAO-A and MAO-B. Being that parnate is very dopaminergic it probably is a much stronger MAO-B inhibitor than nardil.
There was a person who overdosed on 400mg parnate. Autopsy showed no trace of any amphetamine metabolites.
Being chemically related to amphetamine may account for some stimulant effect. It could possibly be a catecholamine activity enhancer like deprenyl even at very low doses is believed to be.
Paul

Thread

Parnate pharmacology. Questionmark 5/19/03
Re: Parnate pharmacology. Paulie 5/20/03
Re: Parnate pharmacology. SLS 5/20/03
Re: Parnate pharmacology. cybercafe 5/20/03
Re: Parnate pharmacology. djmmm 5/20/03
GABA and Euphoria? » djmmm Jack Smith 5/20/03
Re: Parnate pharmacology. Questionmark 5/21/03
Re: Parnate pharmacology. Caleb462 5/23/03
Re: Parnate pharmacology. djmmm 5/23/03
Re: Parnate pharmacology. » djmmm Questionmark 5/23/03

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