Posted by cybercafe on May 20, 2003, at 18:00:49
In reply to Re: Parnate pharmacology., posted by Paulie on May 20, 2003, at 12:18:58
> I noticed more stimulation on 20mg/d parnate than on 45mg/d nardil. What's interesting is that on nardil my MAO inhibition must have been anywhere in the range of approx. 40-95%. On parnate MAO inhibition was probably no greater than 25%. This data is from http://www.vh.org/adult/provider/psychiatry/CPS/17.html
> There is also a chart correlating parnate dosing with MAO inhibition-http://www.vh.org/adult/provider/psychiatry/CPS/17Figure2.html
>
> This is total MAO activity. Wish they had separated into MAO-A and MAO-B. Being that parnate is very dopaminergic it probably is a much stronger MAO-B inhibitor than nardil.
> There was a person who overdosed on 400mg parnate. Autopsy showed no trace of any amphetamine metabolites.
> Being chemically related to amphetamine may account for some stimulant effect. It could possibly be a catecholamine activity enhancer like deprenyl even at very low doses is believed to be.
>
> Paul
>
maybe nardil is less stimulating because it leads to an increase in GABA?
poster:cybercafe
thread:227776
URL: http://www.dr-bob.org/babble/20030520/msgs/227948.html