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Just cuase SSRIs don't work for everyone...

Posted by linkadge on April 23, 2003, at 13:12:58

In reply to Re: What are the best Natural Serotonin enhancers?, posted by stjames on April 23, 2003, at 11:54:42

Most people here know that the sum of all
human happiness is not just Serotonin. We
do know is that SSRI's do two things.


1. Yes they do increase Serotoin, as measured
by spinal metabolite byproduct levels.

2. They relieve depression for many.


The drugs may infact, and probably do
do more than that. But we haven't really
discovered what that is. We also
know that low Serotonin metabolites and
chronic cortisol elevations are among
the few measurable indicators of depression,

(5HTAA only measurable upon death however)

We know there is a strong correlation between
5HT1 receptor expression and violent suicide,
and 5HT2 and sleep. We can induce depression
by lowering Serotoin with Resterpine, and
we can raise it by blocking serotoinin autoreceptors. We know that violent criminals often have a high testosterone/serotoin ratio. We know that 5HTP, the precursor to serotoin can effectivly treat depression in some. We know that there are very few clinically effective antidepressants that have no effect on Serotonin, and that the ones that do are virtually useless in treating suicidal idealation. We know that ECT has robustly alters Serotonin receptor density. We know that MDMA
(while bad for the brain) is possibly the best drug out there for depression, and it enhances the release of serotonin. Lithium raises serotonin and decreases suicide risk.

So, no, thats not all thats going on,
but for goodness sake you'd be a fool
to think that Serotonin doesn't have
a certain deal to do with a whole
lot of peoples problems.

Linkadge


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poster:linkadge thread:221657
URL: http://www.dr-bob.org/babble/20030423/msgs/221765.html