Posted by ace on January 9, 2003, at 2:17:57
In reply to Re: NARDIL: onset of action - please answer!, posted by djmmm on January 8, 2003, at 12:09:41
> well, unfortunately, acetylation (of Nardil) only accounts for a small portion of metabolism.
This statement is in stark contrast to every psychopharacological monograph I've seen on Nardil.> I can't explain the wide range of response times, however, MAO activity is not always directly correlated with response rates.
Do you have any idea what else is?
> Phenelzine, in particular, has a number of active metabolites (including phenylacetic acid and p-hydroxyphenylacetic acid) with direct effects on the GABA and dopamine systems (which may elicit a positive response totally independent of MAOI activity)Are these metabolites definately active? I thought it was never known that Nardil have active metabolites.
> I do believe that some people need a higher dose (90mg), but this dose isn't common. Most people respond to 45-60mgs.
45mg is the starting dose. Have you heard of people responding on this dose? I'd assume it would take ages to respond on this dose. It's not seen as a therapeutic dose, is it?
> I have heard of very long lag times (8 wks) but, again, this isn't common. I think it dependes on the time spent on ramping up to a theraputic dose.
Djmmm - Do you think it is plausible that, REGARDLESS OF NARDIL TAKEN BEFORE HAND (say at 30/45mg) FOR AT WHATEVER TIME FRAME, some OR MOST need people need 4 weeks on 60 mg? For instance, one can spend 2 weeks on 30/45mg, but there must be an addition 4 weeks on 60mg after this for clinical response. Once again, in every standard Nardil monograph I see this.Thanks for all your help. We learn heaps this way! Happy new year, Djmmm.
poster:ace
thread:134761
URL: http://www.dr-bob.org/babble/20030106/msgs/135052.html