Posted by djmmm on January 8, 2003, at 12:09:41
In reply to Re: NARDIL: onset of action - please answer! » djmmm, posted by ace on January 7, 2003, at 22:55:05
well, unfortunately, acetylation (of Nardil) only accounts for a small portion of metabolism.
I can't explain the wide range of response times, however, MAO activity is not always directly correlated with response rates.
Phenelzine, in particular, has a number of active metabolites (including phenylacetic acid and p-hydroxyphenylacetic acid) with direct effects on the GABA and dopamine systems (which may elicit a positive response totally independent of MAOI activity)
I do believe that some people need a higher dose (90mg), but this dose isn't common. Most people respond to 45-60mgs.
I have heard of very long lag times (8 wks) but, again, this isn't common. I think it dependes on the time spent on ramping up to a theraputic dose.
poster:djmmm
thread:134761
URL: http://www.dr-bob.org/babble/20030106/msgs/134959.html