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Thanks, SLS/more questions

Posted by JaneB on October 20, 2002, at 8:04:13

In reply to Re: Claritin helps sexual side effects????, posted by SLS on October 19, 2002, at 23:16:17

> Hi.
>
> Periactin (cyproheptadine) is a drug that possesses several pharmacological actions besides being an antihistamine.
>
> The property of Periactin that can act to reverse sexual side-effects involves serotonin (5-HT). It blocks (antagonizes) 5-HT2 and 5-HT3 receptors. It has nothing to do with histamine.
>
> Claritin (loratadine) does not block 5-HT receptors.
>
> Hope this helps...
>
>
> - Scott
>
>

Scott,
Thanks for the info. Years ago I was given Periactin for trigeminal neuralgia along with another medication (can't remember--25 years ago). While on the Periactin I had the best sleep I could remember. Not realizing at the time I was probably in a pastpartum depression and perhaps the Periactin did more than stop the excruciating pain. Is that possible?

Are there any similarities between Periactin and klonopin or Celexa other than they both make sleep possible? ex. does Klonopin block 5-HT2 and 5-HT3 receptors?
Thanks,
JaneB


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