Posted by Rick on September 8, 2002, at 0:35:14
In reply to Re: Zoloft vs. Nardil for SP??? » Anna M., posted by JonW on September 6, 2002, at 18:11:37
> Dr. Liebowitz from Columbia told me Nardil is the single most effective agent for social phobia
Based on placebo-controlled studies, nothing -- Nardil included -- is more effective at treating Social Phobia than the anxiolytic Klonopin. Admittedly, just because something is the most effective agent in studies that doesn't mean it's necessarily the most effective in the "real world." Nonetheless, 1 mg/day Klonopin is still working wonders for me after three years.
As for JonW,Nardil didn't help me all that much (nor did a 16 week run of Celexa or a 12 week trial of Neurontin or a short trial of Xanax). Also, the Nardil side effects were extremely difficult for me. BUT...
A) I might not have given Nardil enough time to work(and for side effects to abate)
B) With co-morbid depression (which was not a factor for me) it's important to have an antidepressant (many take both Nardil or another AD, AND Klonopin)
C) Nardil's certainly performed much better in SP trials than any other antidepressant, and most importantly, it has an *extremely* good real world track record for SP. Even if it didn't work for me, it seems to help a majority of Social Phobics a lot.I've posted this a few times in the past, but here's the Medline abstract of the Klonopin (clonazepam) study:
J Clin Psychopharmacol 1993 Dec;13(6):423-8
Treatment of social phobia with clonazepam and placebo.
Davidson JR, Potts N, Richichi E, Krishnan R, Ford SM, Smith R, Wilson WH.
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Clonazepam and placebo were administered in a double-blind pilot study to 75 outpatients with social phobia. The mean maximum dose of clonazepam was 2.4 mg/day at endpoint (range, 0.5 to 3 mg). Treatment was continued for up to 10 weeks. The results of an intent-to-treat analysis indicated superior effects of clonazepam on most measures. Response rates for clonazepam and placebo were 78.3 and 20.0%. Drug effects were apparent on performance and generalized social anxiety, on fear and phobic avoidance, on interpersonal sensitivity, on fears of negative evaluation, and on disability measures. Significant differences were evident by week 1, 2, or 6, depending upon the rating scale used. Clonazepam was well tolerated in general, although unsteadiness and dizziness were more severe and persistent than was the case for placebo subjects.
Publication Types:
Clinical Trial
Randomized Controlled TrialPMID: 8120156 [PubMed - indexed for MEDLINE]
Rick
poster:Rick
thread:119071
URL: http://www.dr-bob.org/babble/20020906/msgs/119260.html