Posted by BekkaH on August 5, 2002, at 23:34:39
In reply to Grapefruits, posted by DiscoPuppy on August 5, 2002, at 11:19:41
> Does anyone have any idea why grapefruits should be avoided?
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As far as I know, the only problem with amphetamines would be that the acid in grapefruit juice would increase the rate at which the amphetamine is excreted from the body. Grapefruit juice can be a big problem when combined with some other drugs, however. Grapefruit juice inhibits the cytochrome P450 liver enzymes 1A2, 2A6, 3A and intestinal 3A. It actually inhibits 3A quite a lot, so if you're taking a drug that requires 3A in order to be metabolized, and grapefruit juice is inhibiting 3A, the levels of the drug can build up to dangerous levels. Citalopram/Celexa is a substrate of 3A, so the levels of Celexa might build up if you drink grapefruit juice. There are many other drugs that can be affected by grapefruit juice enzyme inhibition.
poster:BekkaH
thread:115167
URL: http://www.dr-bob.org/babble/20020731/msgs/115361.html