Posted by OldSchool on February 6, 2002, at 12:05:12
In reply to Re: New Celexa...BORING! @ OldSchool, posted by djmmm on February 5, 2002, at 22:44:52
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>
> Eric,
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> also... by bypassing first pass metabolism, the l-amphetamine, and l-methamphetamine metablites are avoided...
>
> Im confused because Selegiline is a poor antidepressant (typically), Do you know the amount of selegiline absorbed through the skin? is it high enough that it is no longer selective to MAO-B?....
>
> ...also you still have to avoid all the medications that are on the MAOI list (ephedra, dextromethorphan, ventolin, etc)
>
> just some links:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7519005&dopt=Abstract
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2491941&dopt=Abstract
> )
Well, selegiline at the doses used for parkinsons is a poor antidepressant from what Ive read. The dose used for parkinsons is 10 mg. At this low a dose selegiline is a selective MAOI, for MAO-B only. At the 10 mg dose used for parkinsons you do not get any MAO-A. MAO-A is where you get the real antidepressant effect from. Parnate, Nardil and Marplan are all irreversible MAOIs and increase both MAO-B and MAO-A at the same time.From what Ive read Selegiline is a pretty good antidepressant IF you take higher doses of it, much higher than 10 mg. At higher doses of selegiline, it loses its selectivity for MAO-B and begins increasing MAO-A. Thus the antidepressant effect kicks in. The problem with this is that as soon as selegiline begins becoming irreversible at the high doses needed to be an antidepressant, the "cheese effect" kicks in as selegiline becomes a plain old regular MAOI like Parnate. Thus the MAOI diet must be followed with dosages above 10 mg.
I read all this stuff over on the tips and tricks of this site. Just look up MAOIs and pick the selegiline link.
poster:OldSchool
thread:91928
URL: http://www.dr-bob.org/babble/20020131/msgs/93077.html