Posted by ben on February 6, 2002, at 7:48:47
In reply to Re: No cheese effect?--COOL-but how?, posted by OldSchool on February 5, 2002, at 20:48:02
I read the german monographies from Selegiline and Moclobemide ant it tells you the following:
1.Selegiline is a irreversible MAO-B inhibitor at low doses (5-10 mg/d p.o.) and loses the selectivity (inhibition of MAO-A too) at higher doses. There is no diet restriction needed BUT it is recommended to avoid tyramine rich food like cheddar...
2. Moclobemideis a reversible MAO-A inhibitor at low doses (-600 mg/d p.o.) and loses the selectivity (inhibition of MAO-B too) when given in higher doses (I guess more than 600/900 mg a day).There is no diet restriction needed BUT it is recommended to avoid tyramine rich food like cheddar...
Some pdocs use Moclobemide up to 1200 mg a day under blood pressure control if patients had only partial response OR are ultra rapid metabolizers (mephenytoin-polymorphism) !Conclusion: No diet restriction for Selegiline and Moclobemide in usual doses. The Cheese-like effect is mechanism based ! - and undepended of the drug form (oral/transdermal/i.v....).
Some points about the amphetamine-like metabolites:
-Do they occur only after first pass metabolism (I dont guess so because your body has to get rid of lipophilic drugs mostly over the liver ) !?
If they have really significant effects we should know the half-life of them and the therapeutic window - to see if our discussion about is really relevant.
-Thought they have no real amphetamine-like effects (and no bad side effects). Is this not an anectotal or are there new informations ?> Now you tell me if that would not be some shit or what? If you could take an MAOI but no MAOI diet?
>
> Old School
poster:ben
thread:91928
URL: http://www.dr-bob.org/babble/20020131/msgs/93054.html