Posted by Ritch on February 6, 2002, at 9:37:49
In reply to Re: What about other AD transdermal patches?, posted by djmmm on February 6, 2002, at 2:25:40
> > > >
> > > > Fascinating discussion (and link) about transdermal antidepressant application of selegiline. What about using a transdermal application for folks that happen to respond to SSRI's (like me), but who have nasty GI side effects from the extra serotonin released from all of the cells that line the GI tract (dyspepsia, GERD, diarrhea)? I wonder if there could be any benefit.
> > > >
> > > > Mitch
> > >
> > > selegiline is a very unique compound, not all antidepressants can be absorbed through the skin...in fact, I don't think any other antidepressants can, so a SSRI patch is out of the question.
> >
> >
> > I just remembered something that probably isn't too important...but..doxepin (Sinequan, Adapin, a TCA antidepressant) used to be available as a topical cream for dermatitis and hives, etc. a topical antihistamine. From what I recall there were warnings about using the cream over large areas of the body due to the absorption of the medication through the skin and it entering the bloodstream.
> >
> > Perhaps more transdermal applications of medications are not ventured because of factors other than *impossibility*. Perhaps it is not *easy* to do, not *practical*, or *marketable*. (little return on investment??)
> >
> > Mitch
>
>
> I was wrong...after some searching, it seems that Buspar was tested in transdermal form, too.
>
> http://www.pslgroup.com/dg/2C1AE.htmWow, I just got another idea here. Maybe a lot of the transdermal delivery research on existing meds has precisely to do with profits?
Buspar is fixing to go generic soon I believe...
that is in pill form.
New delivery systems would guarantee the patent status of that formulation and maintain the income stream from the medication. All of the engineering costs would be involved with the delivery system alone, and subsequent trials wouldn't be as much of a dice throw-as there is already extensive clinical experience with the oral form..hmmmm.Mitch
poster:Ritch
thread:91928
URL: http://www.dr-bob.org/babble/20020131/msgs/93063.html