Posted by kregpark@yahoo.com on January 29, 2002, at 3:22:00
In reply to Provigil Interactions with other meds » Ritch, posted by IsoM on January 26, 2002, at 1:47:07
> Mitch, the P450 Interactions software says that Provigil can both increase & decrease the effect of Celexa 'cause their one or more uninhibited CYP pathways. But both clonazepam & citalopram are metabolised by CYP 3A & modafinil induces or increases 3A so more is available to metabolise the clonazepam & citalopram theoretically lowering the blood levels of them. Seeing induction doesn't happen immediately, I don't suppose it would make any difference in the timing of your meds. I'm nowhere knowledgable enought to hazard a guess.
>
> Incidently, I take Celexa along with adrafinil. I have no idea, sorry to say, how Provigil affects bipolars. I'm simply unipolar with ADHD & narcolepsy.Interesting. If you mean bipolar low I'm impressed that adrafinil is stimulating enough to offset Celexa and then some. I think it is likely more stimulating than provigil, which I take.
On Provigil interaction with Klonopin, the eeffects I get is that more Provigil leads me to take less Klonopin. My guess had been Provigil slowed metabolism of Klonopin. Go figure.
poster:kregpark@yahoo.com
thread:91490
URL: http://www.dr-bob.org/babble/20020124/msgs/91999.html