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Provigil Interactions with other meds » Ritch

Posted by IsoM on January 26, 2002, at 1:47:07

In reply to Re: re: adrafinil Alertec (provigil) avail in Canada » IsoM, posted by Ritch on January 26, 2002, at 0:50:49

Mitch, the P450 Interactions software says that Provigil can both increase & decrease the effect of Celexa 'cause their one or more uninhibited CYP pathways. But both clonazepam & citalopram are metabolised by CYP 3A & modafinil induces or increases 3A so more is available to metabolise the clonazepam & citalopram theoretically lowering the blood levels of them. Seeing induction doesn't happen immediately, I don't suppose it would make any difference in the timing of your meds. I'm nowhere knowledgable enought to hazard a guess.

Incidently, I take Celexa along with adrafinil. I have no idea, sorry to say, how Provigil affects bipolars. I'm simply unipolar with ADHD & narcolepsy.


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