Posted by JohnX2 on January 26, 2002, at 12:57:24
In reply to Prozac akathisia driving me nuts, posted by MB on January 25, 2002, at 21:11:46
A switch to Serzone or a Serzone add on would
probably help. Serzone has had a recent fda
warning, but I don't know the details.
You could also try Remeron standalone, or as
an add-on. Remeron is also a 5ht-2 antagonist.I believe your line of thinking regarding
the 5ht-2 receptor stimulation is correct.Zyprexa may even help, even though it is an
anti-psychotic. The benefits of its 5ht-2 antgonism
are guesstimate ~10x? fold over the dopamine antagonism/tweaking.Another med that may help a pinch is Buspar,
but I think the strong 5ht-2 antagonists are
what you are looking for.Regards,
John
> Even with Klonopin (2mg/day) and LARGE doses of Neurontin (400mg 5 x day) I'm still getting breakthrough akathisia from the Prozac I'm on. I'm also taking 5 mg of Adderall, but that actually *helps* the akathisia. I think the akathisia is from the the way prozac stimulates 5-HT(sub)2 receptors, which in turn antagonizes dopamine action in the striatum. Do you think that if I switched to Serzone (which blocks 5-HT(sub)2 receptors and hence increases striatal dopamine) I would have less akathisia? I've suffered Restless Leg Syndrom all my life and this exacerbation is driving me loony-toons.
>
> MB
poster:JohnX2
thread:91621
URL: http://www.dr-bob.org/babble/20020124/msgs/91688.html