Posted by IsoM on January 7, 2002, at 20:56:10
In reply to Re: Motivation/Focusing Problems on Provigil » IsoM, posted by Mark H. on January 7, 2002, at 20:19:02
I'm not sure if the effects of adrafinil may be a little different than modafinil (Provigil). The reason being is adrafinil forms two main metabolites & one of metabolites is modafinil. So when taking adrafinil you get the benefit of modafinil & adrafinil's other metabolite, both which are active (meaning effective). That may make adrafinil somewhat more effective.
I didn't notice anything at all for the first week but I took a low dose only to make sure there wasn't any side-effects or interactions with other meds. Recommended dose is 400 mg-1200 mg adrafinil. I only took 200 mg that first week. After that I went to 300 mg & after a week on that noticed something for sure. I wasn't certain at first & there's no dramatic change but while the improvement was subtle, it certainly was working.
How long have you been on Provigil? And don't get insulted at this question please, but have you had placebo responses to meds before? I wondered if that may account for your immediate response. Perhaps you need to give the Provigil a longer trial period to reach the full potential.
I think I'm going to stick to 400 mg, maybe a little less in summer when I'm a bit less sleepy. The improvements continued to show even at the 5 week level, but that's when I ran out & my new shipment still hasn't come - X-mas mix-up? I've made sure I ordered lots this time to not have a delay again. In the literature on adrafinil (& I think modafinil), benefits continue to show even at the 3 month level.
It's interesting that the parts of the brain that are activated with Ritalin & Dexedrine are not the same parts that adrafinil & modafinil activate. The first two activate more specific areas but adrafinil & modafinil activate a much larger region, more diverse an area while still affecting the area that Ritalin & Dexedrine do too, but to a lesser extent. Maybe that's why adrafinil suits me well - not enough brain activation in general. :)
> IsoM,
>
> Thank you for your support. May I ask how long you took Adrafinil before it worked well for you, and what your dosage is? Is the effect immediate?
>
> With Provigil, I need to take 2 caplets to get any effect (that is, 400mg) and sometimes an additional 1 in the afternoon. However, the effect is immediate, not cumulative.
>
> I appreciate your kindness.
>
> Mark H.
poster:IsoM
thread:88641
URL: http://www.dr-bob.org/babble/20020103/msgs/89247.html