Posted by SLS on November 6, 2001, at 12:04:08
In reply to Re: Klonopin and Depression » Rick, posted by pat c. on November 6, 2001, at 0:59:44
> Yeh, I definitely need to pursue the possibility Klonopin acts as an antidepressant.
>
> I'd love to live life without it, but I
> can't be a hero. I'm tired of suffering.
>
> Klonopin works great with me (big-time atypical
> depressant).
>
> I'd be interested in reading some of the references, that you mentioned, that indicate
> that Klonopin works on Serotonin, as well as
> GABA.
>
> Thanks.
>
> Pat
Hi Pat.For me, Klonopin definitely has the ability to make me feel more depressed.
Klonopin has been attributed pro-serotonergic properties for quite a few years. I remember this being the case as early as 1988. I believe you will find sufficient references on Medline.
How sure are you that Klonopin is acting as an antidepressant for you, and why? I have no reason to think otherwise, but I am curious. I think Rick's perspective on the use of benzodiazepines is applicable, and I would not think of Klonopin as being some kind of demon if it is working for you. If it somehow leaves you more vulnerable to abusing other substances, that would be a different story.
While we're on the subject, have you ever tried buspirone?
Did Nardil poop-out on you, or did you discontinue it only because of weight-gain? I gained 40lbs. when I took Nardil as monotherapy. However, I experienced some weight loss when it was combined with desipramine. I believe that there is some reduction of appetite. Also, for me, there is a noticeable increase in basal metabolism as is evidenced by lipolysis, thermogenesis, and weight-loss when I experience a significant remission of depression. Although I have bipolar disorder, my depression is predominantly atypical with respect to vegetative features. However, there is no mood-reactivity.
Do you experience mood-reactivity?
- Scott
poster:SLS
thread:83124
URL: http://www.dr-bob.org/babble/20011104/msgs/83334.html