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Re: Klonopin and Depression » pat c.

Posted by Rick on November 5, 2001, at 2:15:29

In reply to Re: Inhibition of MAO-B Increases GABA » JGalt, posted by pat c. on November 4, 2001, at 8:33:04

>I wonder why Klonopin is so effective against atypical depression. It obviously solves the GAD, panic, and social phobia aspects of the disease. I'm also beginning to think Klonopin might have antidepressant action.

Funny how Klonopin -- unlike Xanax -- has a reputation for often *causing* depression. In fact, many medical reviews list this as one of the main risks of Klonopin use, as if it's been clinically proven. I was warned by a user, "it WILL hit you at some point", but it's now 2+ years and counting. Beats me. I guess what some Klonopin users experience is either classic YMMV, or breakthrough depression unrelated to the Klonopin but incorrectly attributed to it.

I did a Medline search on clonazepam and depression, and the only study-based correlations I saw showed Klonopin exerting *anti*-depressant effects -- even when taken alone. There were several references to Klonopin's pro-serotonergic properties, although its pro-GABA effects are probably the most relevant.

Rick


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