Posted by JGalt on November 1, 2001, at 23:05:54
In reply to Re: Stomach Wants to Know: How LONG must I be empty? » Rick, posted by Cam W. on November 1, 2001, at 22:45:32
It is amazing how much more powerful some (emphasis) drugs/supplements can be when taken on an empty stomach as opposed to a full one.
I happen to notice a significant benefit from DL-Phenylaline or N-Acetyl-Tyrosine if taken w/ B-vitamins and Vit. C on an empty stomach (ie, nothing else than maybe a little sugar). This effect is there even w/o selegiline (though much more prominant with). Ephedrine, caffeine, and some other stimulants also seem to work a lot better on an empty stomach. Modafinil I can't comment on, with what little I have I wasn't even going to try it on a more than empty stomach. Many other psychotropic drugs I've tried are either much more powerful if taken on an empty stomach, or have a more rapid onset of action.
As a result of all this, I've found that eating no more than twice a day seems to help keep certain drugs have a more consistant feeling and action, I always keep any drug that I suspect is worsened by food at least 3 hrs after any meal and 1-1.5 hrs before.
Cam, one thing I have to ask you about...you mention that grapefruit and the compound narnigen (contained in grapefruit) inhibit 3A4 enzymes in the liver. I had always previously thought that this was the case as well, but all the backed literature I found claimed that it almost completely only blocked that enzyme in the intestines. Any idea where we found/heard this about it being in the liver and whether or not there's any truth to it?
Rick, I see your point on not being able to distinguish each individual drug's effects. i can certainly understand.
Houstongirl, I agree, its probably not something to experiment with unless you're pretty sure you're not going to have a serious reaction, or you greatly reduce the dosage of the suspected interaction drug to start off with to make sure it doesn't go bad. Indeed the combination of grapefruit plus certain heart meds is rather lethal. I was just looking for a way to get off cheap with drugs I know would not have such negative reactions.
JGalt
poster:JGalt
thread:82868
URL: http://www.dr-bob.org/babble/20011025/msgs/82939.html