Posted by JohnX2 on November 1, 2001, at 12:40:30
In reply to Modafinil+Grapefruit Juice, posted by JGalt on November 1, 2001, at 10:05:01
I'm not sure how modafinil is packaged, but
generally the coatings (waxes,fillers,sugars,
glycerin,gelatin,etc) give the digestive property.The sustained released meds that generally go after
the intestinal route have fillers around them that require a
more neutral ph to break down (so the stomach
acid doesnt cause a meltdown). They tend to sit
around in the intestines and get absorbed slowly.Interestingly as a side note, some meds will goof
up intestinal absorbtion. There is friendly bacteria
in the intestinal track that can get goofed up
by amphetamines for example. Activated
Vitamin B-12 in particular is manufactured in
the intestinal track by bacteria. (There are
sublingual active forms of b-12 for people on
diuretic meds).I'm not sure if this would make a difference with regards
to the liver enzyme trick. The grapefruit juice
or Serzone would inhibit the enzyme in the liver
directly. I'm guessing, but could find out
the exact answer from a pharmacist, that any medication
that requires the liver to metabolize would be
affected regardless of where it is absorbed.
Ulitmately the med gets into the blood plasma
which funnels through the liver.I'll look into this and get back to you.
PS. you are learning too many of the tricks
too fast.-john
> On a post further up on this page "Provigil Poopout: 2 yrs better than ever", Rick posted that one of Modafinil's primary metabolization enzymes was CYP 3A4. Assuming that is the case, it may turn out that instead of using Serzone to increase modafinil's effectiveness, one could use Grapefruit Juice instead, which blocks CYP 3A4. This blockage occurs mostly in the gut, and I do not know whether mod. is metabolised in the gut or elsewhere, but it would certainly be nice if it was in this case. Personally I'd love to have a better/longer acting modafinil at the price of drinking a glass of grapefruit juice a little before taking it. Anyone have any info on whether or not Mod. is metabolized primarily in the gut or elsewhere? Xanax and many other benzo's are affected by it, as well as caffeine and bunch of other drugs, so does anyone have some research on where Mod. is metabolised? I'll get around to looking it up later if no one does, but I overspent my stay online as it is. Just as an aside, is anyone on this board taking benzo's also taking grapefruit juice and thus able to lower the benzo dosage?
>
> JGalt
poster:JohnX2
thread:82868
URL: http://www.dr-bob.org/babble/20011025/msgs/82882.html