Posted by Rick on November 1, 2001, at 18:52:11
In reply to Modafinil+Grapefruit Juice, posted by JGalt on November 1, 2001, at 10:05:01
JGalt
Since I take four meds that can theoretically interact with grapefruit juice (modafinil, clonazepam, nefazodone and omeprazole), I try to subjectively assess any interaction. (Obviously, I can't speak directly to your question of whether grapefruit would potentiate modafinil effects in the absence of Serzone and the other meds.)
What I've found is that grapefruit *may* make me feel just a tad more "up" and feel a tad more of a "dried-out" feeling overall (not "dehydrated" --it's hard to describe).
But this may be just a citricebo effect. Frankly, the grapefruit doesn't seem to make any significant difference in how my meds work. Of course, as CAM pointed out, grapefruits are not created equal, and the fact that I don't eat or drink it in large servings may figure in as well. However, I do -- halfheartedly and probably unnecessarily -- tend to avoid grapefruit on days when upcoming events make me reticent to potentially "mess with success".
One thing's for sure -- whether or not I drink any *caffeine* certainly makes a more noticeable difference than grapefruit (makes me more wired -- surprise, surprise!)
BTW, I take 100 mg/day of modafinil, all in the morning. I found that, at least in combo with the other meds, this works better for me than 200 (as a single or divided dose). But as I said, I'll temporarily bump it to 200 every so often for a little renewed "oomph". I usually get the subtle euphoric feling when I do that.
Rick
> On a post further up on this page "Provigil Poopout: 2 yrs better than ever", Rick posted that one of Modafinil's primary metabolization enzymes was CYP 3A4. Assuming that is the case, it may turn out that instead of using Serzone to increase modafinil's effectiveness, one could use Grapefruit Juice instead, which blocks CYP 3A4. This blockage occurs mostly in the gut, and I do not know whether mod. is metabolised in the gut or elsewhere, but it would certainly be nice if it was in this case. Personally I'd love to have a better/longer acting modafinil at the price of drinking a glass of grapefruit juice a little before taking it. Anyone have any info on whether or not Mod. is metabolized primarily in the gut or elsewhere? Xanax and many other benzo's are affected by it, as well as caffeine and bunch of other drugs, so does anyone have some research on where Mod. is metabolised? I'll get around to looking it up later if no one does, but I overspent my stay online as it is. Just as an aside, is anyone on this board taking benzo's also taking grapefruit juice and thus able to lower the benzo dosage?
>
> JGalt
poster:Rick
thread:82868
URL: http://www.dr-bob.org/babble/20011025/msgs/82923.html