Posted by SLS on October 29, 2001, at 8:58:42
In reply to CA rocket fuel; modafinil pharmacology, posted by Elizabeth on October 26, 2001, at 16:37:59
> Since this discussion ("California Rocket Fuel +++") didn't carry over and I'm still hoping somebody has relevant experience, I'm posting again...
>
> I'm interested in drug combinations involving Remeron and Effexor and possibly other antidepressants, stimulants, etc. Anybody had success with such a combination? I'm particularly (though not exclusively) interested in whether this kind of mix could work when the components by themselves have failed or proven intolerable.
>
> Also, I had a question (in response to something that SLS said) that went unanswered, and I haven't been able to dig up an answer to it either so I'm hoping somebody might know or be able to find out:
>
> SLS said:
> > I'm pretty sure modafinil doesn't inhibit at all the reuptake of dopamine at therapeutic dosages, and binds with low affinity to the DA transporter.
>
> I wanted to know if anybody knows what the K_d is. That would be useful to know.
>
> -elizabeth
I've been feeling less than spectacular, so please forgive my dereliction. I've explored modafinil well enough to feel confident that it is not at this time considered to be active directly upon dopaminergic neurons. I'm sure you can find all of the material necessary to assess this for yourself. Probably the best way to go about things is to call Cephalon directly and speak to one of their pharmacologists. Perhaps they have reconsidered their previous conclusions.You might check this out:
http://www.provigil.com/physician/materials/default.asp
It probably doesn't hurt too much to occasionally treat the brain as a black-box. Provigil seems pretty safe.
- Scott
poster:SLS
thread:81334
URL: http://www.dr-bob.org/babble/20011025/msgs/82552.html