> > BTW, it sounds like you and JahL (don't know about..." /> > > BTW, it sounds like you and JahL (don't know about..." />

Psycho-Babble Medication | about biological treatments | Framed
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Re: Temgesic » Elizabeth

Posted by jojo on August 25, 2001, at 17:01:17

In reply to Re: Temgesic » jojo, posted by Elizabeth on August 24, 2001, at 12:18:22

> > That's why I put the word "race" in quotes. Whatever scientific meaning that it may posess is statistical and says nothing about the individual, but it does refer to one's chance of possessing certain genes, which has an effect on their disease susceptibility and drug response, and is more than just being a fast or slow metabolizer. As to individual drug response, the proof is still in the pudding, as they say.
>
> I understand. (Didn't I put "race" in quotes too? :-) )
>
> > BTW, it sounds like you and JahL (don't know about Neal) would make really lousy heroin addicts.
>
> I've been told that before (by other people who should know).
>
> > Do either of you know if you respond to amphetamine with euphoria.
>
> The only times I've taken amphetamine (Dexedrine and Adderall -- 5 mg was the most I tried of either one), I was on Parnate. I got really jittery and hypertensive. (So that would be a "no.")
>
> > There was an article some years ago about that being a predictor of one's chance of responding to imipramine vs amitriptylene, if one was going to respond to one of them.
>
> I remember. I'd like to see if the result can be replicated.
>
> -elizabeth


elizabeth-
Here's a relevant article regarding "race" and drug reaction:

: Hum Exp Toxicol 1994 Aug;13(8):542-4
Related Articles, Books


Adverse reactions to intravenous N-acetylcysteine in Chinese patients
with paracetamol (acetaminophen) poisoning.

Chan TY, Critchley JA.

Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales
Hospital, Shatin, New Territories.

The incidence of adverse reactions to intravenous N-acetylcysteine (NAC) was studied in 56
Chinese patients with paracetamol (acetaminophen) poisoning. Eight (14%) patients developed
a skin rash (n = 7) or fever (n = 1) mostly during the initial high dose infusion of the antidote. In
four subjects (three with toxic plasma paracetamol levels), the infusion was continued without a
worsening of the adverse reaction. NAC was discontinued in the remaining four subjects in
whom the paracetamol levels were subsequently found to be non-toxic. Intravenous
chlorpheniramine was given to six subjects. All eight subjects completely recovered. In the dose
that is recommended for the treatment of acute paracetamol poisoning, intravenous NAC is
generally safe in Chinese but mild side effects are common. We recommend that the initial
loading dose is given over 60 rather than 15 min.

Publication Types:
Clinical trial


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