Posted by Elizabeth on July 18, 2001, at 17:53:50
In reply to Re: Thorazine and brain damage, posted by Else on July 18, 2001, at 14:00:40
> I took a phenothiazine called Histantil once as a sleeping aid, I don't know if that's the US name. It is chemically related to Thorazine although it is marketed as an anti-emetic. The generic product is called promethazine I think.
Phenergan is the common brand name in the US. Promethazine is a phenothiazine but isn't much of a dopamine antagonist like Thorazine is, which is why it's not used as an antipsychotic. It's just a very strong antihistamine.
> Anyway. It knocked me out cold for 18 hours and I was depressed for 3 or for days after that.
Sounds like you should avoid centrally-acting ("drowsy") antihistamines, then.
> I hate these drugs. And I only took 1 pill of the smallest dose possible (25 mg). I can only nimagine what Thorazine must be like.
Thorazine would probably be different (in a not-necessarily-pleasant way) since it's a dopamine antagonist (that's what makes it an antipsychotic) as well as an antihistamines. Some phenothiazines are more sedating than others (Thorazine is one of the more sedating ones); the sedation is due to various pharmacologic actions.
-elizabeth
poster:Elizabeth
thread:69927
URL: http://www.dr-bob.org/babble/20010714/msgs/70705.html