Posted by PaulB on June 15, 2001, at 12:32:57
In reply to Re: Questions About Adrafinil? » PaulB, posted by Mitch on June 14, 2001, at 23:21:20
> > Given that Remeron enhances noradrenaline at the alpha-1 post-synaptic receptors I shouldnt think Adrafinil would help with Remeron histamine induced sedation. It was my impression that Remeron sedation decreased after the antidepressant started working.
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> I mentioned that because I have noted that Remeron (and atypical and conventional antipsychotics) have *antagonist* properties (which are secondary to their intended receptors) at alpha-1 noradrenergic receptors which *causes* orthostatic hypotension and dizziness (not necessarily drowsiness-H1 receptor activity). I was thinking that if the dizziness component and *possibly* reduced alertness due to the a1 blockade was reversed with an a1 *agonist*, then meds such as Remeron might be more *tolerable* and more *effective*. Allowing the Remeron to function primarily from the 5-HT2 and 5HT-3 antagonism and wouldn't require as large a dose of Remeron to *overcome* the antihistamine sedation.
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> MitchI guess an alpha-1 agonist such as Adrafinil or Modafinil could help. I dont know. Ive heard of antagonists to block agonists but not agonists to block antagonists before. I guess you have to take into account the effaciousness of Remeron, the degree of sedation and whether or not such a combination could be helpful. I think the augmentor Pinodol has a similar action to Remeron, blocking the 5-HT autoreceptors stimulating the release of 5-HT and increasing 5-HT at the 5-HT1a receptors only.
From what I have heard Remeron is the most sedating of all antidepressants alongside Trazadone. It is a potent anti-histamine even at low doses. Thats its first effect.
poster:PaulB
thread:66351
URL: http://www.dr-bob.org/babble/20010612/msgs/66562.html