Posted by PaulB on June 14, 2001, at 12:30:21
In reply to Re: Questions About Adrafinil? » SalArmy4me, posted by Mitch on June 14, 2001, at 10:16:31
> > Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist. The improved learning seen with it may also result from enhancement of vigilance due to facilitation of noradrenergic transmission in the central nervous system. Adrafinil stimulates the noradrenergic post-synaptic receptors and thereby boost alertness, activity and energy. --That's all I could find.
>
> Sal,
>
> 1) Is this currently available in the US?
> 2) I have heard something about it being a new alternative drug for ADHD. Is this true, is it effective?
> 3) Given its pharmaco profile, I wonder if it would be a great augmentor for AD's like Remeron (to reverse drowsiness/dizziness), or atypical AP's that make people feel dizzy that respond well otherwise. (reverse orthostatic hypotension)
> Thoughts??
>
> MitchThanks for the information.
I am not aware of Adrafinil being used for ADHD. The Dopamine class of drugs are best studied for this disorder although Venlafaxine has been used with some success. I should think it would be well worth a trial though.
Given that Remeron enhances noradrenaline at the alpha-1 post-synaptic receptors I shouldnt think Adrafinil would help with Remeron histamine induced sedation. It was my impression that Remeron sedation decreased after the antidepressant started working.
poster:PaulB
thread:66351
URL: http://www.dr-bob.org/babble/20010612/msgs/66466.html