Posted by Mitch on June 14, 2001, at 23:21:20
In reply to Re: Questions About Adrafinil?, posted by PaulB on June 14, 2001, at 12:30:21
> Given that Remeron enhances noradrenaline at the alpha-1 post-synaptic receptors I shouldnt think Adrafinil would help with Remeron histamine induced sedation. It was my impression that Remeron sedation decreased after the antidepressant started working.
I mentioned that because I have noted that Remeron (and atypical and conventional antipsychotics) have *antagonist* properties (which are secondary to their intended receptors) at alpha-1 noradrenergic receptors which *causes* orthostatic hypotension and dizziness (not necessarily drowsiness-H1 receptor activity). I was thinking that if the dizziness component and *possibly* reduced alertness due to the a1 blockade was reversed with an a1 *agonist*, then meds such as Remeron might be more *tolerable* and more *effective*. Allowing the Remeron to function primarily from the 5-HT2 and 5HT-3 antagonism and wouldn't require as large a dose of Remeron to *overcome* the antihistamine sedation.
Mitch
poster:Mitch
thread:66351
URL: http://www.dr-bob.org/babble/20010612/msgs/66528.html