Posted by JohnX on March 8, 2001, at 8:34:01
In reply to Re: Ziprasidone, could be a good one, posted by ChrisK on March 7, 2001, at 5:53:20
> John,
>
> Just jumping into your conversation with Cece but have you considered trying Mirapex, especially with some of the news around here of late?
>
> I've followed some of your woes as they are very close to mine. Although I didn't react at all to SSRI's, I did find a mild boost from Nortriptyline. I've stayed on that for a number of years now as my primary AD. After a couple of suicide attempts about 3 years ago I was started on Zyprexa. It made a world of difference. Zyprexa cleared up my ruminating thoughts and helped me get through some of my anxiety problems at the same time.
>
> Unfortunately I spent the next few years looking for some way to combat the anhedonia without success. I tried Wellbutrin, Adderall, Ritalin, Provigil, almost anything that was supposed to be activating. Nothing got me over the hump..
>
> Last Dec. I asked my pdoc about Selegiline and we agreed that we would both look at possibilities in Jan. When I went back I had found a lot of info on Mirapex and asked him if I could try it. After a few minutes with the PDR and the studies I gave him, we agreed to try it.
>
> It has been the best thing that's happened to me since Zyprexa. I'm down to Norteriptyline, Zyprexa and Mirapex and for the first time in years I can feel my emotions again. It's been 2 1/2 months now and I still feel the good effects.
>
> I know you have followed some of Mirapex threads but it has been great for my anhedonia problem. It may not be for everyone but you might want to give it a try.
>
> ChrisChris,
Thanks for your insights. I'm most definately looking into any dopaminergic medication or 5ht-2 antagonist. My belief is they I have a hypo-dopmanergic prefrontal cortex. This correlates to my symptoms of tension headaches & anhedonia and the meds that relieved the symptoms Adderall, Serzone, and Klonopin.
I'm a little nervous about trying any meds that may cause EPS, because I got a lot of twitching, rls, and my tension headaches got worse after trying SSRI's. The SSRI's really numbed out my emotions bad. I found evidence that SSRI's in some people can induce hypo-dopaminegic activity
that results in side-effects similar to neuroleptics. My other problem is that meds sometimes induce mania. So I've mainly been using anti-convulsants to stabilize my mood with the lingering anhedonia and tension-headaches to be cured. Unfortunately I just moved for a new job and hit a really bad slump and it took me 6 weeks to get into see a new pdoc and this guy is very stubborn. All my old pdocs were very open to letting me try fringe alternatives. In the mean while I switched to meds that I had prior experience with that I knew would get me 80% back to normal with low risk because I was very concerned about loosing my job. From here I can tinker with adding in all these great new suggestions I've found in this news group.Andrew sent me a great list of meds to try, and it included Mirapex (which I haven't got to yet).
How fast does the Mirapex kick in for you?
-John
poster:JohnX
thread:54700
URL: http://www.dr-bob.org/babble/20010302/msgs/55909.html