Posted by JohnX on March 7, 2001, at 4:15:55
In reply to Re: Ziprasidone, could be a good one » JohnX, posted by Cece on March 7, 2001, at 0:12:03
> I'm interested in trying Ziprasidone to see if it might touch what I describe as my "background, chronic demon"- a combo of depressive and anxiety sx which remain despite mood stabilizers, AD's, anti-anxiety meds, and stimulants (all of which have helped much- none of which have really calmed this grinding monster).
> > > Cece
> >
> >
> > Cece,
> >
> > What is the "grinding monster"?
> >
> > In my case the grinding monster (no pun intended)
> > is bruxism (teeth grinding) and chronic tension headaches, as well as anhedonia, bipolar II.
>
> John-
>
> Well, I've been trying really hard to put this into words- but it's a slippery 'demon' who lurks, and is hard to pin down.
> Part of it is chronic muscle tension, especially in my upper body, and when it's bad my whole chest hurts. Sometimes I call it 'chronic grief'. It's also the constant feeling that something is wrong, that there is something I'm supposed to fix if I could just figure it out. And recurring social withdrawal, a feeling of being assaulted by too much stimulus: light, noise, energy. Oh yeah, and headaches- lots of headaches, like there's not room in my head for everything that's fighting in there.
>
> Meds have helped a lot- this all used to be so much worse. But a (dangerous) shadow remains, and I want to chase it down and disarm it. I call it 'grinding' because it is so damn persistent.
>
> Can you relate?
>
> Cece
> >Yeah I can relate. We want to finish off our episodes and move on with our lifes, but this monkey just won't get off our backs!
I'm wondering what kind of headaches do you get?
Are they migraine headaches? (Guessing because of
the sensitivity to noise,light,etc).When I get past any major depressive or manic
episodes, I usually normalize into a state of anhedonia (lack of interest or drive) + I always have these lingering tension headaches. My tension headaches go away when I take a stimulant or Klonopin or Serzone. I've nailed it down physiologically to an area of the brain that when hypo-dopaminergic can cause tension, anhedonia, social withdrawl. Meds that block the serotonin
5ht-2 receptor will relieve these symptoms (they will increase dopamine indirectly in the problem spot; stimulants like Adderall increases dopamine directly). The 5ht-2 blocker include Serzone, and
most of the anti-psychotics like Zyprexa. Have you tried Zyprexa? Serzone made me too drowsy, but Ziprasidone is a potent 5ht-2 blocker that seems to not have the Serzone/Zyprexa like side effects.What do you think?
-John
poster:JohnX
thread:54700
URL: http://www.dr-bob.org/babble/20010302/msgs/55815.html