Posted by JohnX on February 24, 2001, at 17:28:06
In reply to Ziprasidone, could be a good one, posted by Bradley on February 23, 2001, at 15:30:13
>
> The studies on Ziprasidone look promising. You have pobably been informed that it should be available in a week or two. Are any of you planning to give it a try.
> Allthough it has been approved for schitzophrenia it has AD effects. The side effect profile is less than Zyprexa for example(no weight gain).Bradley,
I hope to give Ziprasidone a try. I haven't
ventured much into the realm of anti-psychotics,
but after reading about this one, I think I'll
give it the green flag. I tend to have really
bad teeth grinding and tension headaches which
are exacerbated by SSRI's (this is somewhat rare).
I also have had hypo-manic responses to
anti-depressants. Serzone had a quality (5-ht2
blockade) which releaved my facial pain, but it
made me incredibly drowsy, which was my main
complaint, and it caused weight gain. The
mechanism that seems to contribute primarily to
the weight gain in Serzone and the
anti-psychotics like zypreza all seem to do with a side effect of the 5ht-2 serotonin receptor blockade which causes noradrenaline
(alpha-1) blockade. This alpha-1 blockade
may cause dizziness and drowsiness too.
Ziprasidone looks like the 1st med that substantially relieves this problem and also adds another feature that will reduce anxiety (5HT-1 agonism). I'm hoping this works well for me.Please keep in touch with anyone's Ziprasidone
experiences.Btw, has anyone tried Serzone and Zyprexa like
meds and found the drowsiness profile to be
similar (..we know they both cause weight gain)?
I'm mainly hoping hoping Ziprasidone won't
affect me cogniztively.-John.
poster:JohnX
thread:54700
URL: http://www.dr-bob.org/babble/20010221/msgs/54766.html