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Re: Investigational drug assay and specific receptors.

Posted by Dr. Fried on April 28, 2000, at 0:46:08

In reply to Re: Investigational drug assay and specific receptors., posted by PeterJ on April 27, 2000, at 3:24:24

I am wondering why the newer classes of antidepressants aren't panning out quite as well as would be hoped, which is pretty evident from this message board. The idea that effecting specific receptors to correct a given disorder, does this hold water? Or would it work well in one instance and not another? Also the variabilty of response, what would account for this? Different concentrations of receptors or genetic variability in the specific receptors? If an antidepressant drug could be developed that targeted a specific receptor with very high accuracy and the minimum of interactions with untargeted receptors, would it be expected to work more effectively, or is it still somewhat of a shot in the dark?

I thought that there are bound to be chemicals that would facilitate brain tissue cell culture. I have heard of a naturally occuring compound that is reputed to stimulate nerve growth, maybe in ways unheard of not to far in the past. Something like this might be useful.


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poster:Dr. Fried thread:31294
URL: http://www.dr-bob.org/babble/20000420/msgs/31543.html