Posted by Cam W. on April 13, 2000, at 23:18:46
In reply to Re: Uprima, apomorphine - Cam W?, posted by FP on April 13, 2000, at 21:12:39
> I'm dating myself, but William S Burroughs, the junky and "Beat" writer claimed that Apomorphine permanantly cured his craving for heroin. Has anyone ever examined his claim and debunked it, or could there be something to it?
>
> Thanks,
> FPFP - I dunno about the apomorphine curing his craving for morphine. For the amount of crap he put into his body, I'm amazed he lived as long as he did. Apomorphine is a dopamine agonist, which perhaps raises dopamine signals (or levels) in the nucleus accumbens (pleasure center thought to be involved in the reinforcement of addictions). Most (if not all) drugs to make you "high" or feel good increase dopamine levels in the nucleus accumbens. When the dopamine levels fall after the drug wears off you crave the increase of dopamine in the nucleus accumbens again, so you take another dose. I think this is how reinforcement works. - Cam W.
P.S. - Burroughs, Kerouac, Cassidy, Ginsberg, et al, were a wacky bunch, weren't they?
poster:Cam W.
thread:29285
URL: http://www.dr-bob.org/babble/20000411/msgs/29933.html