Posted by AndrewB on April 12, 2000, at 9:45:11
In reply to Re: clarification, please read everyone(esp. Cam), posted by liz on April 11, 2000, at 8:30:48
Uprima is more commonly known as apomorphine. I guess that Uprima is the trade name that they will market apomorphine under as a medicine for sexual dysfunction. Apomorphine has been around quite awhile and is used as a drug to help with parkinsons disease. It is both a D2 and D1 receptor agonist. Like many other dopamine agonists (bromocriptine, pergolide, lisuride) and dopaminergenics (selegiline), it has been noted to have the ability to enhance sexual function in both men and women. Apomorphine has been used off label for quite some time as a sexual enhancer. Its relatively short half-life (1-2 hours) makes it well suited for this purpose. I believe Uprima will be in a sublingual form. Side effects include nausea, which is common with dopamine agonists. Domperidone, a peripheal dopamine receptor blocker, offsets the nausea but is available only in Europe.
From all that I have read, excepting this CNN story you refer to Liz, apomorphine is a libido enhancer. It works in both men and women. Its action is most probably through the stimulation of the central D2 receptors. Its ultimate action may be due to the release the hormone oxytocin or the lowering of the level of the hormone prolactin. I wonder if the CNN story isn't correct also and possibly these hormones have an effect on vasodialation in the genital area of both men and women.
AndrewB
poster:AndrewB
thread:29285
URL: http://www.dr-bob.org/babble/20000411/msgs/29717.html